Who is more durable? Nissan steel chain CVT gearbox vs Volkswagen 7 wet double clutch

Gearbox dispute: CVT or DCT, who is more resistant to operation?

It is said that there has been another dispute in the automobile circle recently. This time, the steel chain CVT is competing with Volkswagen’s 7-speed wet dual clutch. As a person who doesn’t know anything about cars, my first reaction is: aren’t these two iron boxes installed in cars? What’s there to argue about? But if you think about it carefully, this is not a trivial matter, it is related to our driving experience and the thickness of our wallet!

Speaking of CVT, it’s like a diligent old ox, and he doesn’t make mistakes when he works quickly. It doesn’t have a fixed ratio, just like a mind-reading assistant, it can adjust the speed according to your needs at any time, making you feel as smooth as floating in the clouds when driving. Moreover, this guy is particularly fuel-efficient, and he is simply the best partner of frugal drivers.

However, CVT also has its small temper. In the case of high speed or heavy load, it is a little overwhelmed, just like a long-distance runner who is suddenly asked to lift weights and is a little uncomfortable. Moreover, the internal structure of CVT is quite special, and maintenance may make your wallet thinner.

Let’s talk about the dual clutch. This guy is like a personality fanatic, and the speed of shifting gears dazzles you. It has two clutches, one for odd gears and the other for even gears, which are perfectly matched. It feels like playing a racing game, and you are so responsive that you seem to be a professional driver.

However, this "master" also has his own shortcomings. Complex structure means high maintenance cost, and it may be a bit "pumping" at low speed, just like an eccentric artist, sometimes giving you a little surprise.

After all, these two gearboxes are like friends with different personalities. CVT is a steady and reliable honest person, suitable for friends who like to drive comfortably and smoothly. However, it is the kind of passionate and energetic school, which is more suitable for fans who pursue passion and performance.

As for who is more resistant to exercise? It depends on how you fuck. If you are a gentle driver and often drive around the city, CVT may be more suitable for you. It can not only make your driving more comfortable, but also save you a lot of gas money. But if you are a "speed freak" who loves high-speed driving, those clutches may be more to your taste. It can give you faster response and stronger power output, and let you gallop on the expressway.

However, no matter which gearbox you choose, the most important thing is to take good care of it. Just like taking care of your pet, regular physical examination and regular feeding (oil change) are essential. For CVT, attention should be paid to inspection and replacement or chain to avoid long-term high-load operation. For the dual clutch, it needs to be overhauled in a professional service center. After all, its "temper" is more complicated and needs professionals to "serve".

The article is almost over. I have a question to ask you here: If you had to choose between a smooth and fuel-efficient CVT and a passionate dual clutch, what would you choose? Do you pursue a comfortable economy or prefer passion? Welcome to share your thoughts in the comments section!

The 337th Golden Week welcomes the autumn rain, and civilization and true feelings are supported under the umbrella.

At 3 o’clock on the afternoon of September 30, Yangbei Bayou, the mobile brigade of the traffic police detachment of Suqian City, Jiangsu Province, received an alarm from the masses, saying that a two-car rear-end collision occurred about 1 km south of the Bayou. After receiving the alarm, Li Qiangeng, a policeman on duty, immediately led several auxiliary police officers to the scene to carry out pre-disposal. At that time, the injured fell to the ground, and their consciousness was in a confused state. They quickly found umbrellas from the surrounding area and found pillows to put on their heads. In the nearly 20 minutes of waiting for 120 ambulances, Li Qiangeng always covered his umbrella on the head of the injured person who fell to the ground, regardless of his whole body clothes getting wet by the rain, while comforting the injured person with the injured person not to worry and waiting patiently for the ambulance to arrive.


The identity and labor of cleaners win the respect and recognition of tourists, and the situation of hurting the weak gains the understanding and help of passers-by. A small umbrella opens up a piece of empathy; The small space under the umbrella shares the civilization and human feelings of modern society. Autumn rain is cold and people are warm. Thank you for your umbrellas in the rain!

1 graphics card+a few lines of code: 40% faster for large model training!

I have to say, in order to let more people use the big model, the technical circle is really different!

The model is not open enough? Someone started a free open source version on their own.

For example, DALL·E Mini, which is popular all over the network recently, and Opt-175B (Open Trained Transformer), which is opened by Meta.

It is all through the way of re-engraving that the original big model that is not open enough becomes available to everyone.

1 graphics card+a few lines of code: 40% faster for large model training!

Others think that the model is too big for individual players to bear the sky-high cost.

Therefore, methods such as heterogeneous memory and parallel computing are proposed to speed up and reduce the cost of large model training.

For example, Colossal-AI, an open source project, has just realized that an NVIDIA RTX 3090 can single out a large model with 18 billion parameters.

1 graphics card+a few lines of code: 40% faster for large model training!

In these two days, they came up with a new wave:

Seamlessly support Hugging Face community model, and only add a few lines of code to realize low-cost training and fine-tuning of large models.

1 graphics card+a few lines of code: 40% faster for large model training!

You know, Hugging Face, as one of the most popular AI libraries, provides the realization of more than 50,000 AI models, which is the first choice for many AI players to train large models.

The Colossal-AI operation is to make the training and fine-tuning of the open model more practical.

And the training effect has also improved.

On a single GPU, compared with Microsoft’s DeepSpeed, Colossal-AI’s automatic optimization strategy can achieve 40% acceleration at the earliest.

Traditional deep learning frameworks such as PyTorch can no longer run such a large model on a single GPU.

For parallel training using 8 GPUs, it can be realized by adding -nprocs 8 to the startup command.

1 graphics card+a few lines of code: 40% faster for large model training!

After this wave, it can be said that the cost, efficiency and practical problems that individual AI players need to consider are all grasped ~

No need to modify the code logic.

All talk and no practice.

Let’s take OPT as an example, and expand it in detail to see how the new functions of Colossal-AI can be used.

OPT, the full name is Open Pretrained Transformer.

It was released by Meta AI, and compared with GPT-3, the maximum parameter can reach 175 billion.

The biggest feature is that GPT-3 does not disclose model weights, while OPT opens all codes and weights.

Therefore, every developer can develop personalized downstream tasks on this basis.

The following example is to fine-tune Casual Language Modelling according to the pre-training weights provided by OPT.

Mainly divided into two steps:

1. Add a configuration file

2. Start the operation

The first step is to add a configuration file according to the task you want to perform.

For example, on a GPU, taking heterogeneous training as an example, it is only necessary to add relevant configuration items to the configuration file, without changing the training logic of the code.

For example, tension _ placement _ policy determines the strategy of heterogeneous training, and the parameters can be CUDA, CPU and auto.

The advantages of each strategy are different, and the adaptation situation is different.

CUDA: All model parameters are placed on the GPU, which is suitable for traditional scenes that can still be trained without unloading.

CPU: All the model parameters are placed in the CPU memory, and only the weights currently involved in calculation are reserved in the GPU memory, which is suitable for the training of super-large models.

Auto: According to the real-time memory information, automatically determine the amount of parameters to be kept in GPU memory, which can maximize the utilization of GPU memory and reduce data transmission between CPU and GPU.

For ordinary users, using auto strategy is the most convenient.

In this way, Colossal-AI can automatically and dynamically select the best heterogeneous strategy in real time to maximize the computational efficiency.

from colossalai.zero.shard_utils import TensorShardStrategy

zero = dict(model_config=dict(shard_strategy=TensorShardStrategy(),

                              tensor_placement_policy="auto"),

            optimizer_config=dict(gpu_margin_mem_ratio=0.8))

The second step is to insert a few lines of code to start the new function after the configuration file is ready.

First, start Colossal-AI with a configuration file through a line of code.

Colossal-AI will automatically initialize the distributed environment, read the relevant configuration, and then automatically inject the functions in the configuration into components such as models and optimizers.

colossalai.launch_from_torch(config=’https://news.mydrivers.com/1/845/configs/colossalai_zero.py’)

Then, the data set, model, optimizer, loss function and so on are defined as usual.

For example, using native PyTorch code directly, when defining the model, you only need to initialize the model under ZeroInitContext.

Here, the OPTForCausalLM model and pre-training weights provided by Hugging Face are used to fine-tune the Wikitext dataset.

with ZeroInitContext(target_device=torch.cuda.current_device(), 

                    shard_strategy=shard_strategy,

                    shard_param=True):

    model = OPTForCausalLM.from_pretrained(

                ‘facebook/opt-1.3b’

                config=config

Next, just call colossalai.initialize to inject the heterogeneous memory functions defined in the configuration file into the training engine, and then start the corresponding functions.

engine, train_dataloader, eval_dataloader, lr_scheduler = colossalai.initialize(model=model,

                                                                               optimizer=optimizer,

                                                                               criterion=criterion,

                                                                               train_dataloader=train_dataloader,

                                                                               test_dataloader=eval_dataloader,

                                                                               lr_scheduler=lr_scheduler)

Still have to rely on GPU+CPU heterogeneity

The key to enable users to achieve the above "fool-like" operation is that the AI system itself should be smart enough.

Gemini, an efficient heterogeneous memory management subsystem of Colossal-AI system, plays a core role.

It is like a manager in the system, which dynamically allocates the memory of CPU and GPU after collecting the information needed for calculation.

The specific working principle is to preheat in the previous step and collect the memory consumption information in the dynamic calculation diagram of PyTorch.

After preheating, before calculating an operator, using the collected memory usage records, Gemini will reserve the peak memory required by this operator on the computing device, and at the same time move some model tensors from GPU memory to CPU memory.

1 graphics card+a few lines of code: 40% faster for large model training!

Gemini’s built-in memory manager marks each tensor with a state information, including HOLD, COMPUTE, FREE and so on.

Then, according to the dynamically queried memory usage, the tensor state is dynamically changed and the tensor position is adjusted.

The direct benefit is to maximize the model capacity and balance the training speed under the condition of very limited hardware.

You know, the mainstream method of ZeRO (Zero Reduency Optimizer) in the industry, although it also uses the method of CPU+GPU heterogeneous memory, will still cause problems such as system crash and unnecessary traffic due to static division.

Moreover, by using dynamic heterogeneous CPU+GPU memory, memory can also be expanded by adding memory bars.

It’s much more cost-effective than buying high-end graphics cards.

1 graphics card+a few lines of code: 40% faster for large model training!

At present, using Colossal-AI method, RTX 2060 6GB ordinary game instinct training 1.5 billion parameter model; RTX 3090 24GB host directly hits the big model with 18 billion parameters; Tesla V100 32GB can even win 24 billion parameters.

In addition to maximizing the use of memory, Colossal-AI also uses distributed and parallel methods to continuously improve the training speed.

It proposes complex parallel strategies such as data parallelism, pipeline parallelism and 2.5-dimensional tensor parallelism.

Although the method is complex, it is still very "fool’s operation" to get started, and it can be realized automatically by simple declaration.

There is no need to invade code like other systems and frameworks, and handle complex underlying logic manually.

parallel = dict(

pipeline=2,

tensor=dict(mode=’2.5d’, depth = 1, size=4)

)

What else can Colossal-AI do?

In fact, since the open source, Colossal-AI has been ranked first in the world in the hot list of GitHub and Papers With Code for many times, and it is well-known in the technical circle.

In addition to training a large model with a single GPU as mentioned above, Colossal-AI can double its performance and reduce its resources to less than one tenth when it is extended to large-scale parallel scenes with dozens or even hundreds of GPUs, compared with existing systems such as Megatron-LM in NVIDIA.

In terms of conversion, the cost savings can reach millions of yuan on pre-training GPT-3 and other super-large AI models.

1 graphics card+a few lines of code: 40% faster for large model training!

According to reports, Colossal-AI related solutions have been used by well-known manufacturers in autonomous driving, cloud computing, retail, medicine, chips and other industries.

At the same time, they also attach great importance to the construction of open source community, provide Chinese tutorials, open user community forums, and constantly update iterations according to everyone’s feedback.

For example, we found that a fan left a message asking whether Colossal-AI could directly load some models on Hugging Face.

Well, this update is coming.

1 graphics card+a few lines of code: 40% faster for large model training!

So, what difficulties do you think need to be solved urgently for large model training?

"0 contact" to see a doctor, how to develop Internet medical care under the catalysis of epidemic situation in the future?

In fact, the Internet medical industry entered a bottleneck period in previous years. Policy restrictions are on the one hand, and the industry itself has many problems to be straightened out. For example, Internet medical care has at least two problems that cannot be ignored, namely, the quality and safety of medical care. Considering the particularity of medical behavior, for example, western medicine needs to see, touch and listen, Chinese medicine needs to look, hear and ask questions, and the diagnosis and treatment mode of face-to-face communication is ruled out. What is the accuracy of Internet medical diagnosis results? Accuracy-based medical safety geometry? In other words, does Internet medical care have the possibility of first consultation?


In this regard, Zhu Hengpeng, director of the Public Policy Research Center of China Academy of Social Sciences, said after the State Council issued the Opinions on Promoting the Development of "Internet+Medical Health" that this restriction was to ensure the quality and safety of medical services, which reflected the highly cautious attitude of the Health and Health Commission. However, he also pointed out that it is not that the first Internet consultation must surpass the first offline consultation in terms of safety and service quality, and it should be allowed by the policy. Instead, it should be judged whether the first Internet consultation is not inferior to the first offline consultation under the conditions of comprehensively weighing the four factors of improving the accessibility of medical services, reducing costs, improving efficiency and ensuring quality. In addition, in addition to quality and safety issues, Internet medical care still needs to be improved.


First, the relevant laws and regulations are not perfect and lack effective supervision.Internet medical treatment is still a new industry. At present, some laws and regulations are not perfect, which makes the Internet medical treatment industry lack comprehensive and effective supervision and restriction. For example, information security issues such as privacy leakage that may exist in the use of consulting services, telemedicine and mobile medical equipment need to establish a set of privacy protection laws and regulations that are suitable for the national conditions.


Second, some medical institutions hold a wait-and-see attitude towards "Internet+medical care".The main purpose of "Internet+medical care" operation is to solve the contradiction between the imbalance of medical services and the growing demand for health services by the masses. However, the current medical institutions, especially public medical institutions, are unable to let go of medical talents, and the conservative wait-and-see between departments has restricted the development of "Internet+medical care" to some extent.


Third, doctors’ "pain points in practice" need to be concerned.At present, most online doctors are still organizations with the status of compilation, and online "sharing" may mean offline "loss". There is still a long way to go to realize the combination of online and offline doctors, and to ensure that patients can easily obtain electronic prescriptions while online diagnosis and treatment, so as to complete the purchase of drugs.


Although there are still many places that need to be improved and perfected, Internet medical care still has great development potential in the long run. If Internet medical care does not stop at a short-lived prosperity during the epidemic, it must try its best to overcome various obstacles that affect long-term development. Its core lies in the efforts to promote the multi-party linkage development environment of medical institutions, doctors, Internet companies, etc., to form a complete and standardized closed-loop medical service and realize real "digital health".


In the future, Internet medical care should strive to grasp the demands of all parties and take demand as the source of development.There are still many pain points in China’s traditional medical service system, such as difficult and expensive medical treatment, and the demands of all participants for Internet medical care are obvious. In this context, Internet medical enterprises need to think from the perspective of users’ needs, and seek application models and business models centered on users’ needs in the fields of medical services, public health, medical security and drug management.


The smart medical service model of "big data+artificial intelligence" will play an important role in promoting the development of Internet medical care. Intelligent medical products integrate disease monitoring, health management and decision-making, which can realize the interaction between patients and medical personnel, medical institutions and medical equipment, and gradually achieve informationization. I believe that in the near future, Internet medical care will be integrated with more high technologies such as artificial intelligence and sensing technology, so that medical services will become truly intelligent.

"Love on the Island": "Beautiful love is not to be missed"

  The large-scale island dating reality show "Love on the Island" created by the local team of Guangdong Satellite TV, which carries the positive energy of a new generation of young people’s love and dating, has also set off a wave of island tourism. Starting from the idea of building the Belt and Road tourism development in China, the program shows the vigorous vitality of contemporary youth in China to the world by integrating the beautiful scenery of Southeast Asian islands along the Maritime Silk Road with guests.

  What is worth looking forward to is that this large-scale island dating reality show "Love on the Island" will be held onThis Saturday at 22:00Meet with you again, Manado!

  With the deepening of the third lens, we not only gradually unveiled the mysterious veil of this charming island Manado, but also with the further promotion of the emotional line of the program, the emotions of the nine guests also collided with fierce sparks. "In today’s society, there is not much love full of positive energy, especially the romantic performance of Luo Yun and Fang Lan in the program, which seems to see themselves who worked hard for love in the past." Netizens expressed their views after watching the third program.

  What wonderful clips have appeared in this issue of "Love on the Island" that make netizens sigh so much? Let’s find out!

  The choice between friendship and love? River valley rafting staged a heart-wrenching test

  In the third episode just aired, we experienced the turbulent side hidden in the beautiful jungle of Mina-the drifting of Baishui River. At the beginning of the program, nine guests need to try their best to compete for the air pump of the hull. The quick-eyed Lincoln and Yu Wen won the most efficient air pump and were the first to prepare the hull for sailing in the envious eyes of all the guests.

  Lincoln and Yu Wen, who have fully proved their strength, are bathed in the joy of victory. At this point, an embarrassing thing has attracted people’s attention. It turned out that the sunrise, Romeo and Luo Yun simultaneously extended a helping hand to Lincoln. On the one hand, he is a good buddy on the road, and on the other hand, he is a sweetheart who doesn’t agree with himself but always has hope, which makes Lincoln fall into deep hesitation. In order to make the beloved person not so hard, this balance finally leans towards the group of Guan Xi. He handed the air pump by himself and told Bian Ce, Guan Xi’s partner, "Don’t let Guan Xi work so hard in the next link", which showed his full manly charm.

  Old love is still the most beautiful! Island owner Yang Sen said with emotion after witnessing the whole process. From the acquaintance on the uninhabited island in the first phase to the stumbling in the tropical rain forest in the second phase, this is actually the projection of many young people making friends in tell it to the judge today. The female guest Yan Xi dares to love and hate, and the male guest Lincoln bravely strives for love. This scene also conveys to the audience a positive view of love, which is full of feelings and is told in a creative reality show way.

  Luo Kai falls in love "Xiuluochang" and sounds love alarm along the dangerous river.

  At the end of the canyon drifting, such an unexpected plot happened.

  In the dangerous and fast-flowing Baishui River basin, the competition among nine guests has also been heated up. At this time, the sky darkened in an instant, and the rainstorm suddenly came. The river was like a tap that was opened wide in an instant. The unprepared guests had to go ashore to find ropes under the guidance of experienced boatmen and planned to cross the Baishui River.

  "At that time, the current was particularly urgent. If you step on the air carelessly, the consequences will be unimaginable." This is the guest’s pertinent evaluation of the danger at that time. However, at this time, an awkward atmosphere spread quietly among the people. When the guest partners helped each other down the hillside to cross the river, Luo Kai, a male guest, left his partner Fang Lan to help Rong Rong because of carelessness or ulterior motives. The female guest who noticed something was wrong immediately called Luo Kai back to help his partner Fang Lan, while Fang Lan, a "female man" at this time. At that time, the delicate relationship between the two suddenly fell into an unprecedented crisis.

  Romantic banquet table true feelings fancy love explodes the girl’s heart

  This week, "Romantic Dinner" was launched again. As a "mysterious person", Liu Han revealed his views on love for the first time through poetry. "I have a heart willing to make green leaves for you." He has always been a guest of dark line observation. At this moment, he also presented meaningful flowers to four female guests to show his affection for one of them.

  The most appetizing thing is that male and female guests choose each other to talk, which is the first time that male and female guests have opened their hearts since the broadcast. The male guests started the age of love mode one after another. Lincoln first sang a song "Little Lucky" and invited Xian Xi to have a profound dialogue. The two finally solved the entanglement in their hearts and exchanged gifts to make a deep friendship. Not to be outdone, Romeo, an Italian man, extended an olive branch to his partner Rong Rong, walked barefoot on the grass, gave a shell necklace and other "Italian" confession methods to win Rong Rong’s heart;

  The plot of Luo Kai and Fang Lan’s reconciliation of grievances makes the love of this program warm up to the highest point. Fang Lan, who was angry with Luo Yun before, took Bian Ce as the object of heart-to-heart. However, Luo Yun’s sudden appearance stopped the dialogue between them, and the two of them quarreled as a bee in the night. The impatient Luo Yun posed a love with a personal photo on the grass. "You only have yourself in your world," Fang Lan complained, "but when there is another person in the middle of love, it may be different."

  There is loss, hesitation, mixed with happiness and romance, which may be the truest embodiment of today’s young people’s love. The love tree between guests has set a benchmark for making friends with positive energy. Love on the Island meets you at 22:00 every Saturday night in Manado Island! Stay tuned!

Enter the demonstration zone of common prosperity and focus on the high-quality development of Yuhang.

Walking into the demonstration zone of common prosperity and focusing on the high-quality development of Yuhang-Botuo Bio # # #

The epidemic situation in COVID-19 has caused a sharp increase in social demand for infectious disease detection, which is the leading industry in market demand growth in recent years. What is the market size of the current testing market? What is the future development prospect of testing industry? This time, the straight flush expert group interviewed Mr. Song Zhenjin, Secretary of the Board of Directors of Botuo Bio (688767.SH), and talked about the rapid development of Botuo Bio in the past two years, the company’s future strategic planning and the industry market.

Guest introduction:Song Zhenjin, Secretary of the Board of Directors of Hangzhou Botuo Biotechnology Co., Ltd., used to be the department manager of Tianjian Certified Public Accountants (special general partnership) and the financial controller of Songdu Service Group Co., Ltd.

Interview details:

(1)

Straight flush expert group:Can you introduce the domestic market situation and future expectations of POCT industry?

Song Zhenjin, Director of Botuo Biology:At present, compared with the overseas market, the domestic market demand for POCT and family self-test products is far from being released. In the future, with the promotion of national graded diagnosis and treatment, the control of medical insurance fees, the popularity of family self-test and the COVID-19 epidemic, the public and government departments pay much attention to infectious disease detection, the domestic market demand is expected to be further released. From the perspective of industry market scale, the fastest growing year of POCT industry in China is 2020, with a growth rate of 24.70%. According to the data of China Blue Book of Medical Devices (2021), the market size of POCT industry in China will be around 9.3 billion yuan in 2020, and it is predicted that the market size of POCT in China will exceed 26 billion yuan by 2026.

(2)

Earth egg Niu Niu:What is the company’s current competitive advantage and moat?

Song Zhenjin, Director of Botuo Biology:The company has always focused on the field of POCT inspection, engaged in the research and development, production and sales of in-vitro diagnostic series products, committed to promoting the high-quality development of human diagnosis, and adhered to the concept of leaving complexity to itself and bringing convenience to users. The company’s current competitive advantages and moats mainly include the following points:

(1) It has the advantages of a mature and efficient technology platform. By using the latest modern biotechnology such as monoclonal technology, immunochromatography technology, protein coupling technology and nano-scale colloidal gold labeling technology, the company has established a reaction system for colloidal gold immunochromatography diagnosis and detection of target proteins or small molecular substances. Using this technology platform, a series of rapid detection products with high sensitivity and good specificity can be developed quickly, efficiently and stably.

(2) Mature R&D system and abundant technical reserves. Based on the mature rapid immunodiagnostic reagent product technology platform, aiming at the deficiency of the original immunochromatography technology such as colloidal gold in quantitative detection, the company successfully developed 18 reagents such as myocardial series, inflammatory series and sex hormone series during the reporting period, and obtained relevant registration certification, realizing the rapid quantitative detection of related biomarkers. At the same time, the company has rich technical reserves. In terms of technical route, the company has carried out technical layout based on the molecular diagnosis technology platform, and has reserved key technologies related to molecular diagnosis products such as rapid nucleic acid extraction technology, multiplex fluorescent quantitative PCR technology, ARMS-qPCR technology, RT-LAMP technology and extraction-free rapid fluorescent PCR technology, and has developed molecular diagnosis products such as multiple nucleic acid detection reagents for respiratory infectious diseases. In the field of chemiluminescence, The company uses magnetic particle chemiluminescence technology to build a fully automatic chemiluminescence detection platform. In the research field of microfluidic technology, the company will focus on promoting the layout of micro total analysis system technology in fluorescence immunoassay and nucleic acid detection product lines, and focus on the application of high-sensitivity detection technology in non-laboratory environment. On the product line, the company’s products have expanded from qualitative to quantitative, and immunology to molecular diagnostics; The animal disease detection technology platform has realized the extension of the company’s detection products from human medical diagnosis to animal medical diagnosis.

(3) A stable R&D team with international vision. The company has established a technology research and development center in San Diego, USA, which is at the forefront of the world biomedical engineering science and technology field, laying a good foundation for the subsequent training of various R&D talents, and undertaking the functions of absorbing the most advanced technology in the international biomedical engineering science and technology field and cultivating senior R&D talents. During the reporting period, the company was awarded the Zhejiang Provincial Enterprise Research Institute. By June 30, 2022, the company had obtained a total of 201 intellectual property rights, including 162 domestic and 39 overseas, including 12 invention patents, and the R&D investment was 69,309,500 yuan, an increase of 155.72% over the same period.

(4) Rich product lines and complete registration and certification advantages. As major countries in the world have clear access thresholds and strict regulatory measures for the production, registration and circulation of in-vitro diagnostic products, they can only be sold in the local market after obtaining the corresponding product qualification certification. The company has a professional domestic and foreign product registration team and is familiar with domestic and foreign laws, regulations and registration procedures. By the end of June 2022, the company had 327 EU CE certificates, 3 FDA 510(k) certificates, 1 Australian TGA certificate, 1 Thai FDA THAILAND certificate and 1 Brazilian ANVISA certification. At the same time, the company has 40 NMPA certificates in China (including 30 third-class certificates). The continuous enrichment of product line series and relatively complete product certification have laid a solid foundation for the company’s products to open the global POCT market and enhance the global market share.

(5) Advantages of marketing channels. The company’s marketing network has covered five continents and nearly 120 countries or regions around the world, with a group of very high-quality customers who have maintained long-term and stable cooperation. With the good reputation and channels of COVID-19 antigen products, the company has developed many new markets and new customers such as Russia, Australia, Canada, Mexico, Argentina, Peru, Colombia and Ecuador. In the post-epidemic era, the company can quickly push non-COVID-19 products to the above markets, thus bringing new sales performance. In the international market, many of the company’s own brands, such as Right Sign, have won the export famous brand in Zhejiang Province for many years, which has a high reputation and has been widely recognized by customers. Advin Biotechnology, an American subsidiary, is the company’s R&D and sales center in the United States, providing localized production and services, ensuring that the company keeps up with the technological development trend of the global in vitro diagnosis industry and continues to provide customers with technologically advanced and high-quality products and services. In the domestic market, the company’s sales network has basically covered major provinces in the country and has a relatively stable customer channel. The company’s products have been online in Jiangsu, Zhejiang, Guangdong, Anhui and other provinces that have provincial-level sunshine procurement or medical reagent consumables platforms, and have a certain popularity and customer recognition. Drug testing products have been selected as qualified suppliers and product catalogues of drug testing kits selected by the Ministry of Public Security. Detection products such as Helicobacter pylori and hepatitis B have been widely used in screening and evaluation projects of high-risk groups in various provinces and cities.

(6) Development and self-production capacity of core biological raw materials. Establish a biological core raw material technology platform, and form an overall biological raw material technology platform composed of multiple technologies. Including antigen coupling technology, gene recombinant protein expression technology, monoclonal antibody development technology and so on. We have developed a series of core raw material products, including cocaine antigen, ethyl glucuronide antigen, pregabalin antigen, clozapine antigen, anti-human red blood cell antibody, anti-morphine antibody, fentanyl antibody and anti-ethyl glucuronide antibody. Bochuang Bio, a subsidiary, is mainly engaged in the research and development of biological raw materials, forming a research and development team of about 20 people. Up to now, the company’s five series of products: 20% specific biological raw materials have achieved self-production substitution, and the goal of self-sufficiency in important raw materials will be achieved in the future.

(3)

Straight flush expert group:Based on the global epidemic prevention and control situation and current policy trends, what is the next development plan of the company’s COVID-19 business?

Song Zhenjin, Director of Botuo Biology:With the normalization trend of COVID-19 epidemic overseas, our company has combined the routine business detection products of infectious diseases with COVID-19 products, and has developed multi-inspection products of infectious diseases such as COVID-19 and influenza and obtained CE certificates. In addition, our company will develop new detection forms of COVID-19 detection products to further broaden the quality and variety of COVID-19 detection products. In terms of registration, the company has applied to the US FDA for registration of COVID-19 antigen OTC products, which is currently awaiting approval. In terms of raw materials, the company gradually replaced the self-produced raw materials on the core biological raw materials of COVID-19 products, reducing the production cost and improving the product performance. On the market side, we are also seeking to promote the bundled cooperation mode with high-quality customers and further increase the market share of our products in the local market. In terms of brand, the company is further expanding the marketing channels of COVID-19’s own brand, and further increasing the word-of-mouth construction of the company’s own brand.

(4)

Straight flush expert group:The company’s performance has grown rapidly in the last two years. Can you share the company’s growth strategic plan in the post-epidemic era?

Song Zhenjin, Director of Botuo Biology:The company’s future growth plan mainly includes the following points:

1. Drug detection products,

1) With the further expansion of the traditional dominant market, the drug testing market in the United States will grow greatly in the future. The legalization of some cannabis states will lead to the growth of the consumption population of cannabis drugs, which will further generate a large number of testing demands. The newly developed and competitive product, the prototype product of cannabis saliva, will continue to increase in the American market. In the future, we will also strive to introduce more advantageous products to the market.

2) Explore new regional markets. The new markets developed by the company, such as Russia, Australia (including Australia and New Zealand), Canada and Mexico, are making continuous efforts. Russia is one of the major drug testing markets in the world, and has cooperated with Russian customers and started to sell.

2. With the normalization of epidemic situation, the demand for routine infectious disease detection products has recovered, and the periodic outbreak of influenza and Covid-19 have spawned the demand for multiple detection. The company has developed multiple detection kits for influenza A and B and COVID-19, and obtained certificates and other multiple detection products to meet the market demand.

3. The existing five series of product categories and technical upgrades, such as fluorescent immunoassay products, have obtained more than 20 certificates at present, and more fluorescent immunoassay products will be put on the market in the future. Molecular diagnostic products and products of animal disease detection platform are getting certificates one after another, and considering the research projects and products of many companies at present, expanding these new products, new markets and adding new customers will become the driving force for the revenue growth of non-COVID-19 products in the future.

(5)

Straight flush expert group:What is the layout direction of animal testing market and the competitive advantage in the same industry? What’s the strategic arrangement?

Song Zhenjin, Director of Botuo Biology:At present, the global veterinary testing market is about 40 billion US dollars, and in 2020, there will be about 8 billion domestic veterinary in vitro testing market, including 3 billion in the breeding animal market and 5 billion in the pet testing market, with a compound annual growth rate of 17%. At present, the domestic pet disease detection products are small in volume, but the unit price and profit are good, and the demand for pet disease detection is also increasing rapidly. In addition, in terms of the demand for inspection of cultured animals, animal infectious diseases such as swine fever and avian influenza have obvious fluctuations, which requires the company to have the ability of rapid research and development and response. The company is very optimistic about the potential market of animal disease detection. Based on the animal disease detection platform, we have formed detection products such as canine distemper virus detection reagent, canine coronavirus detection reagent and canine parvovirus detection reagent. At the same time, the company has also made sufficient technical reserves in the detection of avian influenza and other animal diseases.

(6)

Straight flush expert group:What is your understanding and opinion on the future development trend of in vitro diagnosis industry, and what are the main strategies at the company level?

Song Zhenjin, Director of Botuo Biology:COVID-19 has changed the trend and pattern of IVD industry all over the world. The outbreak of Covid-19 has made POCT in vitro diagnostic kit with high detection speed and low detection cost an important means to detect Covid-19, and at the same time, it has also changed and cultivated people’s cognition and usage habits of quick diagnosis products. It is believed that in the future, with the attention and policy support of governments and medical systems in various countries for sudden public health emergencies, the global in vitro diagnostic kit will usher in rapid development. COVID-19 has also brought great opportunities to the company’s development. At this stage, we mainly accumulate and precipitate the cash flow, brand and channel advantages brought by COVID-19, and transform them into the company’s technological advantages and brand advantages to enhance the company’s overall competitiveness. In the future, the company will continue to increase capital investment in the research and development of core biological raw materials in the IVD field, expand raw material research and production business, achieve self-sufficiency in important raw materials, accelerate the industrialization process of new platforms such as molecular diagnosis platform, animal disease detection technology platform and microfluidic technology platform, upgrade the mature rapid immunization technology platform products, continuously launch a series of differentiated and competitive new products, and increase investment in channel construction. Deeply cultivate key markets such as North America, Europe and Asia, and further explore and develop new markets. In addition, according to the characteristics of the industrial chain and the development direction of the industry, the company will also consider industrial investment, mainly looking for high-quality targets that can complement the company in technology, strategy and products, thus enhancing the company’s core competitiveness.

Network Information Office of Yuhang District Committee, Yuhang District Development and Reform Bureau (Financial Office) and Flush into six listed companies in Yuhang are in progress, and interviews will be released in October, so please pay attention!

Reporting/feedback

The National Development and Reform Commission responded to eight hot spots, which are related to work and "food, clothing, housing and transportation"

  BEIJING, March 6 (Zhongxin Finance Xie Yiguan Shao Wanyun) How do you view the economic growth target of around 5%? What is the price and employment situation this year? How to play the pulling role of "Troika"? How to ensure food security and energy security?

  On the 6th, the State Council Office held a series of press conferences on the theme of "Opening by Authoritative Departments". Zhao Chenxin, Li Chunlin and Yang Yinkai, deputy directors of the National Development and Reform Commission, attended and responded to many hot issues.

  Talk about GDP

  — — The expected target of about 5% is in line with the trend of economic operation.

  The government work report puts forward the main expected targets for this year’s development, in which the GDP will increase by about 5%.

  In Zhao Chenxin’s view, the expected target of about 5% conforms to the trend of economic operation and the law of economic development, and is also conducive to guiding all parties to pay more attention to improving the quality and efficiency of economic development, accelerating the construction of a new development pattern and promoting high-quality development.

  "We have made statistics and analysis. Among the 31 provinces, autonomous regions and municipalities, 27 provinces have higher expected targets than the whole country, among which 23 provinces have 5.5% or above. The development confidence and pragmatic measures taken by various localities have created conditions and laid the foundation for the realization of national goals." Zhao Chenxi said.

  Talk about prices

  — — Have confidence and ability to achieve the expected goal of CPI this year.

  According to the government work report, the main expected target of CPI for the whole year is an increase of about 3%.

  "This year, due to geopolitical conflicts, imported inflation risks and other multiple factors, domestic price operation still faces some uncertain and unstable factors." Li Chunlin said, but we must see that China’s grain has been abundant for 19 years, and it has remained above 1.3 trillion Jin of grain for many years. The bumper harvest of grain is the biggest "ballast stone" for us to ensure stable prices.

  "At the same time, the pig production capacity is reasonable and abundant, the commodity supply is sufficient, the energy security is strong, and the system of ensuring supply and stabilizing prices is further improved. It can be said that the foundation for maintaining the stable operation of prices is very solid, and we have the confidence and ability to achieve the expected goal of CPI this year. " Li Chunlin said.

  Video: National Development and Reform Commission: Have confidence and ability to achieve the expected target of CPI this year. Source: China News Network.

  Talk about consumption

  — — It is predicted that consumption will become the main driving force of economic growth this year.

  Final consumption is the lasting driving force of economic growth. At the national level, it has been repeatedly emphasized that restoring and expanding consumption should be given higher priority.

  Li Chunlin pointed out that from the consumption figures during the Spring Festival, China’s consumption has accelerated since the beginning of the year. At present, some uncertain factors restricting the release of consumption are gradually being eliminated. With the rapid release of consumption potential, the growth rate of major indicators in the consumption field is expected to gradually pick up in the first half of the year. Looking forward to the whole year, consumption can become the main driving force of economic growth and better play a fundamental role in economic growth. This is a prediction of the consumption situation this year.

  "In the new year, there are many policy tools in our policy toolbox to deal with the unfavorable factors that restrict consumption. We have the confidence and ability to ensure the implementation of measures to promote consumption this year, and make consumption make greater contributions in the annual growth rate of about 5% of GDP. " Li Chunlin said.

  Talk about investment

  — — Further strengthen the key role of investment in optimizing the supply structure

  In terms of investment, Yang Yinkai said that this year, we will continue to do a good job in expanding effective investment, solidly promote the construction of major projects, effectively promote the investment of the whole society through government investment and policy incentives, focus on consolidating the good momentum of steady growth of infrastructure investment and manufacturing investment, and further enhance the key role of investment in optimizing the supply structure.

  According to Yang Yinkai, focus on the following four aspects: First, focus on short-board areas and weak links, and accelerate the construction of key areas; Second, give full play to the role of various investment policies and promote the construction of major projects as a whole; Third, strengthen the project reserve and continuously improve the quality of preliminary work of investment projects; The fourth is to further stimulate the vitality of private investment and continuously optimize the investment environment.

  Talking about foreign investment

  — — We will encourage foreign investment to deepen the China market with a more open and inclusive attitude.

  "China’s new characteristics of increasing the total amount of foreign investment and optimizing its structure fully demonstrate the global investors’ investment in China’s development ‘ Confidence vote ’ 。” Yang Yinkai said that in attracting foreign investment this year, we will steadily expand the institutional opening of rules, regulations, management and standards, and strive to create a market-oriented, rule-of-law and international first-class business environment to provide support for global investors to invest in China. In the key work, including the orderly promotion of telecommunications, Internet, education, culture, medical care and other fields.

  Yang Yinkai also stressed that China has always been an "activist" in opening to the outside world at a high level, and we will encourage foreign investment to deepen the China market with a more open and inclusive attitude.

  Talk about employment

  — — The employment situation will stabilize and improve.

  Employment is the biggest and most basic livelihood. Li Chunlin said that from this year’s situation, the external environment has become more complicated and severe. The number of domestic college graduates and urban employment demand have reached new highs, and employment expansion and quality improvement still face some pressures and challenges. However, we must also see that with the steady growth, stable employment and stable prices, the business entities such as enterprises will resume development, which will lead to the expansion of employment demand and the increase of jobs, and the employment situation will be stable and good.

  "Last year, we set a new employment target of 11 million people, and actually completed 12.06 million people, 1 million more than the planned target. The target set this year is about 12 million people, 1 million more than last year’s target, which fully reflects our confidence and determination to stabilize employment. "

  Talking about food security

  — — The string of ensuring national food security cannot be relaxed for a moment.

  In recent years, the international grain market fluctuates greatly, and food security has become a common concern.

  Zhao Chenxin said that on the whole, China’s grain supply and price stability foundation is solid, grain production has been bumper year after year, market regulation has been continuously improved, the circulation system is safe and reliable, the inventory is at a high level, and the ability to cope with major natural disasters and public emergencies has been continuously improved. The overall food security situation is good, and the food supply can meet the daily consumption of the people and the development needs of related industries.

  However, Zhao Chenxin also pointed out that China has a population of more than 1.4 billion. Solving the problem of eating well has always been the top priority in governing the country, and the string of ensuring national food security cannot be relaxed for a moment. On the one hand, do a good job in grain production. On the other hand, fully guarantee market supply.

  Talking about energy security

  — — Comprehensive policy to ensure safe and stable supply of energy

  Energy security is an important part of national security, and it is a typical "big country". "Overall, China’s energy security is guaranteed." Li Chunlin said that in 2023, the international energy supply and demand situation is still complicated and there are many uncertain factors; The recovery and development of domestic economy has driven the steady growth of energy demand, and the contradiction between regional and periodic energy supply and demand still exists.

  Li Chunlin said that in order to ensure stable energy supply and price, we will continue to strengthen the construction of energy production, supply, storage and sales system on the basis of preliminary work, and comprehensively implement policies to ensure safe and stable energy supply. First, increase energy production and supply; Second, continue to consolidate energy reserves; The third is to keep energy prices stable; The fourth is to resolutely keep the bottom line of people’s livelihood.

The price reduction of Mercedes-Benz EQE in Qingdao is coming, and the latest offer is 348,000! Preferential treatment waits for no man.

[car home Qingdao Preferential Promotion Channel] Recently, we learned from Mercedes-Benz dealers that a large-scale preferential promotion activity is being carried out in Qingdao. The highest discount has reached an astonishing 130,000 yuan, and the lowest starting price has dropped to 348,000 yuan. If you have a car purchase plan, you may wish to click "Check the car price" in the quotation form to get a higher discount.

青岛地区奔驰EQE降价来袭,最新报价34.8万!优惠不等人

The front face design of Mercedes-Benz EQE adopts a unique starlight grille, and the brand’s iconic starlight pattern is embedded inside, which is not only beautiful but also full of scientific sense. The air intake grille adopts a closed design, which shows its pure electric identity. At the same time, it is matched with LED headlights and daytime running lights on both sides, making the whole front look sharper and more dynamic. Overall style, EQE follows the design language of Mercedes-Benz family, with smooth lines and coordinated body proportions, showing a unique charm of combining modernity and classics.

青岛地区奔驰EQE降价来袭,最新报价34.8万!优惠不等人

Mercedes-Benz EQE has a length, width and height of 4,969 * 1,906 * 1,514 mm, a wheelbase of 3120mm, and a front track of 1634mm and a rear track of 1,645 mm. The body lines are smooth and elegant. Both the front and rear tires adopt the specifications of 255/45 R19, and the fashionable and dynamic rim design further improves the visual effect and driving stability of the whole vehicle.

青岛地区奔驰EQE降价来袭,最新报价34.8万!优惠不等人

Mercedes-Benz EQE interior adopts luxurious and modern design style, and the center console is equipped with a 12.8-inch touch screen, which supports voice recognition control of multimedia system, navigation, telephone, air conditioner and sunroof. The steering wheel is made of high-quality leather, with electric up-and-down and forward-and-backward adjustment functions, providing excellent grip and comfort. The car is also equipped with three front-row Type-C interfaces and two rear-row USB/Type-C interfaces, as well as the wireless charging function of the front-row mobile phone, which is convenient for passengers to use mobile devices. In terms of seats, the main and co-pilot seats are made of imitation leather, which provides multi-directional adjustment functions such as front and rear adjustment, backrest adjustment, height adjustment (4-way), leg rest adjustment and lumbar support (4-way). In addition, the front seats also have heating and ventilation functions, further improving the ride comfort. The rear seats support proportional reclining, and the space can be flexibly adjusted as needed. In addition, the driver’s seat and the co-pilot seat are also equipped with electric seat memory function, which is convenient for drivers and passengers to quickly adjust to the most comfortable position.

Mercedes-Benz EQE is equipped with an efficient motor with a maximum power of 300kW and a maximum torque of 858N·m, which provides a strong power output and a smooth driving experience for the vehicle.

Car home car owners’ evaluation of Mercedes-Benz EQE is: "I think it’s good. It may be ordinary at first sight, but the real car is still pretty good. It is that the taillights are a bit like BYD. " This evaluation not only affirmed the aesthetic feeling of EQE design, but also pointed out the uniqueness of its taillight design.

Present situation and prospect of natural childbirth in China

  Pregnancy and childbirth are normal physiological processes of human reproduction, and most women can naturally give birth to healthy babies. Cesarean section is an important means to solve dystocia, deal with serious pregnancy complications and save the lives of mother and baby.

  In recent years, with the development of perinatal medicine, the conditions of operation, anesthesia technology and drug treatment have been gradually improved, and the safety of cesarean section has been continuously improved. At the same time, the cesarean section rate has been increasing all over the world.

  Twenty-one medical institutions were randomly selected from Beijing, Yunnan and Zhejiang to participate in the World Health Organization (WHO) Global Survey on Pregnancy and Perinatal Care (2007-2008), and the survey results were published in The Lancet magazine in February 2010.

  The average cesarean section rate in the three continents (Asia, Latin America and Africa) participating in this survey is 25.7%, of which Asia is 27.3%, while China is 46.5%, ranking first among the 24 countries participating in the survey.

  The report also pointed out that in China, the cesarean section rate with non-medical indications accounts for 11.7% of all cesarean sections, ranking first among the sampling countries; In Viet Nam, which ranks next to China, the cesarean section rate is 35.6%, but the cesarean section rate without medical indications is only 1%.

  The cesarean section rate in China has far exceeded the WHO standard of reducing the cesarean section rate to below 15%. The rapid increase of cesarean section rate and the decrease of natural delivery rate have brought heavy economic burden to society and families, and also wasted great health resources.

  1. Present situation of natural childbirth in China

  In the 1950s and 1970s, the natural delivery rate in China was around 95%. Since then, with the progress of medical technology and the improvement of material living standards, the natural delivery rate has been declining, and the cesarean section rate has been increasing year by year. After the 1980s, it quickly rose to 30% ~ 40%, and almost reached 40% ~ 60% in the 1990s.

  In the 21st century, cesarean section has become more common. The cesarean section rate in most domestic urban hospitals is above 40% ~ 60%, and a few may be higher. The wide application of cesarean section has not reduced the perinatal mortality. Compared with natural delivery, the relative risk of maternal death has risen, which has a greater impact on the follow-up of maternal and perinatal children and increases the consumption of health resources, which has become another serious public health problem in China.

  Zhu Xuanbo and others found that the cesarean section rate was 37.6% from 1993 to 2010 in the study of cesarean section rate of singleton primiparous women and pregnant women in some areas of China. Pregnant women require 10.0% cesarean section.

  The rate of cesarean section in southern cities increased from 29.4% to 58.7%, in southern rural areas from 18.2% to 58.3%, and in northern rural areas from 4.3% to 49.5%. Among them, the rate of cesarean section required by pregnant women in southern cities increased from 0.6% to 21.3%, up 34 times; From 0.6% to 24.4% in southern rural areas, it has increased by 40 times;

  The rural areas in the north increased by 44 times from 0.6% to 27.3%. Pregnant women’s request for cesarean section accounts for the main part of cesarean section.

  In 2006, the National Institutes of Health,NIH) and the American College of Obstetricians and Gynecologists (ACOG) put forward the definition and principles for the cesarean section required by the mother of this singleton pregnancy without clinical complications.

  It is defined as Cesar can delivery on cesarean section (CDMR) requested by the mother. The principle of handling CDMR is that the decision should be individualized and ethical, and CDMR should not be performed unless there is evidence of fetal lung maturity before 39 weeks of pregnancy.

  At the same time, delivery institutions should provide effective pain management for all delivery women, and pain should not be the reason for choosing CDMR. Mothers who need to have multiple children do not advocate CDMR.

  Therefore, clinicians in China should refer to the suggestions of NIH and ACOG, fully inform pregnant women of the advantages and disadvantages of CDMR, and avoid improper timing of elective cesarean section without clear indications, so as to reduce the increasing cesarean section rate.

  At present, China is at the peak of fertility, and it is estimated that the peak will continue until 2015 before it will gradually stabilize. Nowadays, most young expectant mothers are only children, and fear of pain and convenience has become an important reason for them to choose cesarean section during delivery.

  Superior living and working conditions weaken people’s tolerance for pain. For today’s healthy young women, there is nothing more painful than having to endure pain for more than ten hours when giving birth. The fear of "pain" urges them to choose cesarean section during delivery.

  In addition, compared with natural delivery, cesarean section does not need a "long" wait, and "one knife" can solve the problem. For the above reasons, the number of pregnant women who choose cesarean section, especially primiparas, is increasing.

  ACOG and SMFM jointly issued the first obstetrical care consensus No.1 & mdash; Safely avoid the first cesarean section.

  It is suggested that doctors weigh the short-term and long-term advantages and disadvantages of cesarean section and vaginal delivery, and avoid the abuse of cesarean section safely and effectively, especially the first cesarean section. The common causes of the first cesarean section were analyzed by consensus, and the results were as follows: abnormal labor process, abnormal fetal heart rate monitoring, abnormal fetal position, multiple pregnancies and suspected macrosomia.

  In view of the above reasons, the consensus puts forward a series of intervention measures, including redefining abnormal labor process and reducing unnecessary intervention in labor process; To provide non-medical support during labor and improve the recognition ability of fetal heart monitoring;

  Carry out the application of external gluteal inversion; Reasonable nutrition guidance during pregnancy to prevent macrosomia; It is suggested that cesarean section should not be used as far as possible in twin pregnancy with the first fetus as the head position. The suggestions put forward by this consensus have a guiding role in reducing the delivery rate of first cesarean section in China.

  At present, with the liberalization of the second child policy, not only will there be a group of pregnant women who will have two children for the first time in the future, but also a group who will be pregnant again after cesarean section. In the past, most countries preferred elective cesarean section for those pregnant women with a history of cesarean section (CS). In 1999, Lu Lini reported 1174 cases of cesarean section, of which 137 cases were cesarean section again, accounting for 11.6%, while in 2003, the rate of cesarean section again in the United States was as high as 89.4%.

  Therefore, it is widely discussed in the industry that the second cesarean section will obviously increase the bleeding during maternity and postpartum, the rate of blood transfusion, infection, bladder and intestinal injury and the incidence of deep venous thrombosis. At the same time, pelvic adhesion caused by previous surgery also increases the difficulty of surgery. Newborns are also prone to transient dyspnea.

  Therefore, since 1996, the United States began to encourage pregnant women with a history of CS to choose vaginal delivery (VBAC) when they are pregnant again. ACOG began to advocate VBAC in 1999. However, after nearly ten years’ efforts, there are still many difficulties to be solved, especially the possibility of uterine rupture and the risk of maternal and fetal failure in trial delivery.

  In 2005, the Society of Obstetricians and Gynaecologists of Canada (SOGC) published the second edition of Clinical Guidelines for Vaginal Delivery after Cesarean Section, which reviewed the contraindications of trial of labor, TOL) after Cesarean Section and its impact on pregnant women and fetus, and made an evidence-based assessment of the safety of VBAC.

  It is believed that obstetricians should discuss the risks and benefits of VBAC with pregnant women who are willing to accept TOL. If the previous cesarean section was a transverse incision of the lower uterus and there was no contraindication to VBAC, the pregnant women should be advised to take TOL.

  In order to ensure the safety and effectiveness of VBAC, the parturient should go to the hospital where emergency cesarean section can be carried out. During the labor process, we should closely monitor whether there is any abnormality between the mother and the baby, and deal with it in time if there is any abnormality. It is safe and reliable to use oxytocin to induce labor.

  When the parturient is willing to accept induced labor and knows its risks, it is feasible to induce labor for the parturient with clear indications. Prostaglandin E2 and prostaglandin E1 are not recommended for induced labor during TOL. If the cervical maturity is low during TOL, Foley catheter can be used to soften the cervix. Although the success rate is not high, it will not increase the risk of uterine rupture.

  At present, many large-scale case series studies have confirmed that VBAC is relatively safe. The domestic and foreign literature reports that the success rate of vaginal trial delivery after cesarean section is 60% ~ 80%, and the uterine rupture rate of patients with transverse incision of lower uterine segment after previous cesarean section is only 0.1% ~ 1.5%.

  Therefore, vaginal delivery after cesarean section can effectively reduce the incidence of uterine rupture, improve the success rate of vaginal delivery, and also play a positive role in reducing postpartum maternal and child complications.

  In the mid-1950s, Friedman established the standard of normal delivery progress and delivery curve by evaluating the labor process data of 500 primiparas admitted to Sloane Hospital in new york, and the delivery curve was called Friedman’s labor process diagram or labor process standard.

  This standard has been used to evaluate and manage the delivery process of lying-in women and played a certain role. However, in the practice of obstetrics and anesthesia, it is found that with the development of human society, the natural process of childbirth has changed because of the delay of marriage and childbearing age, the increase of pregnant women’s body weight and the increase of fetal body weight. Managing the labor process according to Friedman’s labor process standard has greatly increased obstetric interventions such as artificial rupture of membranes, widespread use of oxytocin and abuse of instrumental midwifery.

  In recent years, some evidence-based medicine research results reflecting the changes of natural labor process have been published one after another. The unanimous conclusion is that Friedman labor chart is no longer suitable for today’s obstetric clinic, and it is recommended to abandon it.

  The National Institute of Child Health and Human Development (NICHD), the American Maternal and Fetal Medical Association (SMFM) and ACOG jointly recommended the use of new labor progress standards to manage the labor process. In 2014, experts from the Obstetrics and Gynecology Branch of the Chinese Medical Association also put forward a new standard of labor process and an expert consensus on its handling, advocating the popularization and use of new standards of normal labor process and abnormal labor process in China’s obstetric clinical work, and further observing and summing up experience in the implementation, so that this new standard of labor process can play a role in reducing unnecessary labor process intervention, reducing cesarean section rate and ensuring maternal delivery safety.

  Many pregnant women in China choose cesarean section because they are unwilling to endure the pain of natural delivery. However, the development of painless delivery in China is still in its infancy, and there is still a big gap with developed countries in Europe and America. In developed countries, the labor analgesia rate is over 80%, and the cesarean section rate is less than 20%, while the labor analgesia rate in China is less than 1%, but the cesarean section rate is 50%.

  Increasing the rate of labor analgesia can effectively reduce pregnant women’s fear of labor pain and help reduce cesarean section by at least 5%, or even more.

  The situation that the natural delivery rate is continuously low and the cesarean section rate remains high in China has attracted the attention of the state. In 2011, China Maternal and Child Health Association launched the project of "promoting natural delivery and ensuring the well-being of mother and baby", and adopted a series of measures at the national level to "cool down" cesarean section.

  The overall goal of the five-year project is to create a social environment and concept to promote natural childbirth, popularize appropriate midwifery techniques and standardized health education contents and methods to promote natural childbirth, reduce unnecessary cesarean section and maternal and infant mortality, and establish an incentive mechanism to promote natural childbirth through the establishment of training centers, the formation of missionary teams, the cultivation of technical backbones, and the improvement of safeguard measures.

  Popularize appropriate techniques and measures to promote natural delivery and improve medical staff’s cognition and handling ability of maternal and infant complications; Standardize the health education guidance to promote natural childbirth; Raise public awareness of promoting natural childbirth; Effective use of maternal and child health care technical service resources, reduce non-medical indications of cesarean section, improve and protect the health of women and children.

  In 2010, the Health Department of Sichuan Province also vigorously advocated natural delivery and reduced the cesarean section rate, and included the reduction of cesarean section rate in the target assessment of hospitals, requiring all hospitals in the province to reduce the cesarean section rate by 5 percentage points on the original basis. It is believed that under the control of the government, the high cesarean section rate in China can be curbed.

  2. Prospect of natural childbirth in China

  With the harm of cesarean section to parturient and newborn being paid attention to by the state and obstetricians, and the increase of measures to promote natural delivery, such as labor analgesia, doula companionship, the improvement of midwifery technology, the reduction of episiotomy rate of natural delivery, the increase of breech inversion, and the liberalization of national second child policy, prenatal health education and publicity for pregnant women, diet control during pregnancy, strengthening exercise, reducing the first cesarean section, and advocating VBAC.

  The current cesarean section rate has been declining year by year in recent years, and the mode of intrapartum service has also changed from the mode of intervention to the mode of giving priority to the safety and health of mother and baby, and advocated providing humanized and individualized services to pregnant women in physiology, psychology and environment.

  Continuous physical, psychological and emotional support to the parturient during the delivery process makes the parturient feel comfortable and safe, and can cooperate with the medical staff to spend the delivery process safely and happily, thus achieving the purpose of promoting natural delivery.

  Organized by the Women’s Health Branch of the Chinese Preventive Medicine Association, the women who gave birth in 9 medical and health institutions such as Beijing Maternity Hospital from November 2000 to June 2001 were taken as the research objects, and the influence of accompanying delivery on the labor process, maternal and infant outcome and maternal psychology, the feasibility of appropriate delivery technology and the influence of changing the health care model during delivery on pregnancy outcome were studied by using the control research method. The results showed that vaginal delivery accounted for 85.5% in the accompanying group, which was significantly higher than that in the control group (66.0%). Cesarean section accounted for 8.1% in the labor group, which was significantly lower than that in the control group (28.6%).

  The emergency labor rate, postpartum hemorrhage rate and neonatal asphyxia rate in the accompanying labor group were also significantly lower than those in the control group. Compared with the control group, the degree of mental stress, worry and fear in the accompanying group was significantly reduced, while those who relaxed and cooperated with the labor process were significantly higher than the control group. It shows that the appropriate delivery service mode can increase the natural delivery rate, reduce the cesarean section rate and improve the prognosis of mother and baby.

  The application of new labor chart is strongly advocated in the world and China, which can reduce unnecessary labor intervention, reduce cesarean section rate and ensure the delivery safety of pregnant women.

  At present, China’s cesarean section rate is as high as 46.2%, ranking first in the world, which brings heavy economic burden to the country, society and families and wastes great health resources. Therefore, it is the responsibility and obligation of contemporary medical workers to improve the natural delivery rate and reduce the cesarean section rate.

  It is possible to promote vaginal delivery and reduce the cesarean section rate to less than 30% on the premise of the safety of mother and baby through pre-pregnancy health care, pregnancy education and obstetric clinic, but the WHO’s proposal of less than 15% is unrealistic in China.

  Because WHO put forward this standard around 1985, the present situation has changed a lot compared with that time. And the basis for WHO to propose this goal comes from countries with a majority of multiparas.

  At present, the delivery in our country is mainly primiparas, and even multiparas, about 50% people have a history of cesarean section. It is a challenge for China to improve the natural delivery rate and reduce the cesarean section rate. We have a long way to go to truly attach importance to maternal and child health.

Go deep into the grassroots, touch the truth and do a good job in research

In March, 2023, the Central Office issued the "Work Plan on Carrying out Investigation and Research in the Whole Party", which pointed out: "The CPC Central Committee decided to carry out investigation and research in the whole party as an important part of the theme education carried out in the whole party to promote the comprehensive construction of a socialist modern country and make a good start." Investigation and research is the heirloom of our party and the basic skill of doing all the work well.
The General Secretary of the Supreme Leader pointed out that young cadres "should not only’ go into’ the grassroots, but also’ go to’ the grassroots, listen to the truth, examine the truth, really study problems and study real problems". During the period when the general secretary put forward the great concept of "people’s democracy in the whole process", I cherished the precious opportunity of "listening to the truth and examining the true feelings", adhered to the fine tradition of "coming from the masses and going to the masses" and listened to the thoughts and aspirations of grassroots cadres and the masses. Insist on proceeding from reality, understand and master the real situation, concentrate on thinking about grassroots governance and other issues, and earnestly "really study the problem and study the real problem." In the specific investigation and practice, some understandings on how to do a good job in investigation and research have been formed.
First, around the "Three Persistences", find a good research question
Adhere to the major decision-making arrangements of the party and the state. Closely around the party and the country’s major principles and policies and important decision-making arrangements, thoroughly understand the central spirit. Focusing on the central task and decision-making needs of the CPC Central Committee, we should dig out key issues in key areas of concern to the party and the state, and think through the contents that need to be investigated as much as possible. Grasp the urgent task, focus on the overall, key and crucial issues, concentrate on thinking and in-depth analysis, study and sort out the valuable list of research topics, put forward an outline with moderate thickness, form interview questions in line with the actual situation, and effectively enhance the pertinence and accuracy of research.
Adhere to the mass line. General Secretary of the Supreme Leader stressed: "The mass line is the lifeline and fundamental working line of our party, and it is an important heirloom for our party to maintain its youthful vitality and combat effectiveness forever." In the process of investigation, it is very important to obtain valuable information and adhere to the magic weapon of the mass line. Chairman Mao Zedong once said, "The main point is to make friends with the masses, not to be a detective, which makes people hate. People don’t tell the truth because they don’t know whether your coming here is beneficial to them. During the conversation, give them some time to explore your heart and gradually let them know what you really mean, so that the masses can treat you as a good friend and then investigate the real situation. The masses don’t tell the truth, don’t blame the masses, only blame themselves. " We should persist in working diligently at the grass-roots level, cross the threshold of the unit, enter the hearts of the masses, dive into the grass-roots, sink to the front line, and concentrate on the grass-roots, make friends with the masses and become one with them. Build a working mechanism around the three issues of "what do the masses want", "what do we have" and "how to do better", closely follow the work field and focus on the hot, difficult and painful points that the masses care about.
Insist on seeking truth from facts. General Secretary of the Supreme Leader pointed out that "investigation and research must adhere to the principle of seeking truth from facts and establish a pragmatic style". Investigation and research should pay attention to objective factual basis, adhere to the style of seeking truth and being pragmatic, and take a hands-on attitude, anchor some specific problems, distinguish between truth and falsehood, between falsehood and reality, thoroughly understand the upper feelings, understand the lower feelings, find out the inside story, deeply analyze the background and causes of problems and phenomena, avoid presupposing conclusions, and establish a foundation for summing up valuable, reproducible and popularized practical characteristics.
Second, through the "three combinations", find the right research methods
Through the combination of "point" and "surface", the research object is selected correctly. The investigation should be widely covered. The wider the coverage, the more information you know. However, energy and time are always limited, so it is very important to choose the method of "point". Comrade Mao Zedong once said, "There are three typical types of investigation: first, advanced, second, intermediate and third, backward. If we can investigate two or three in each category according to this classification, we can know the general situation. " The General Secretary of the Supreme Leader stressed that it is necessary to "go deep into the grass-roots units to seek advice, and dissect more sparrows to see the big picture". According to these instructions, we can select "sparrows" in a targeted way, collect and understand the situation in an all-round and multi-level way, and fully understand and master the actual situation. For example, the the National People’s Congress Standing Committee (NPCSC) Law Commission has set up 32 grassroots legislative contact points in the country, which are divided into central, western and eastern regions according to different regions; According to the contact point, it is divided into grass-roots political power units, municipal and district government working institutions, institutions and enterprises. According to the establishment time, four batches of 32 companies were established in seven years. According to these characteristics, we can choose a few points from each type to dissect the sparrow.
Through the combination of "eyesight" and "brain power", find the real problem. General Secretary of the Supreme Leader stressed, "Keep your eyes down and your feet down, always dive down and sink to the front line, go near and far, look at the good and bad, listen to the praise and criticism of cadres and the masses, and truly understand the situation." We must persist in going deep into the grassroots, seeing and experiencing with our own eyes, listening to the truth of the masses, finding out the real situation and finding the real problems.
The General Secretary of the Supreme Leader emphasized that "we should make great efforts in in-depth analysis and thinking, select the essence from the rough, discard the false and retain the true, so as to find the essence and laws of things and find solutions to problems from the outside to the inside". On the basis of in-depth investigation, we should conduct systematic and thorough research and in-depth thinking, and refine, systematize and theorize the scattered and perceptual information collected.
Through the combination of eyesight and brain power, we can make a good combination of investigation and study, and practice the eye-catching of finding problems, grasping the essence of things, finding out the internal relations of things, and thus drawing accurate conclusions.
Last year, when receiving the task of legal advice on the revised draft of the company law, the contact point of Hongqiao Street grassroots legislation actively entered the Changning District Federation of Industry and Commerce and related enterprises to listen to their opinions and suggestions. According to the situation reflected in the visit, the problems encountered by enterprises were analyzed. After systematizing scattered information, a legislative consultation forum with the theme of "consulting with legislative opinions, embodying good laws and good governance, and creating a good business environment" was designed, and foreign capital, domestic capital, Taiwan capital and Hong Kong capital were invited to participate in democratic legislation and experience open legislation to realize the interaction of "four businesses". This activity, precisely because it went deep into the grass roots and found out the situation, finally achieved a good research effect, enhanced the experience of different groups on democratic practice, made them willing to tell the story of democracy in China, and made democracy in China more influential.
Through the combination of "seeking truth" and "seeking depth", do a good job in-depth interview. "Seeking truth" is to treat the interviewee sincerely and really find the truth of the problem. In the process of investigation, we must abide by the belief of "people-oriented", exchange people’s hearts for people’s hearts, look at problems from the standpoint and perspective of the masses, and connect the two sides with sincerity. "Seeking the depth" means deepening the interview in order to deeply understand the truth. Interview is the best way to get first-hand information. We should stick to the principle of "drilling a well deep": go deep into the grassroots to understand the specific situation, find the real problems in depth, and go deep into the masses to understand what is urgently needed. In addition, when sorting out the interview materials, we should fully brainstorm, give full play to the value of the collected materials, and think deeply, analyze deeply and summarize deeply.
During my tenure, in order to find out what the neighborhood committee secretary is busy with, which is a major issue related to grassroots governance, I investigated and learned about the daily work of 21 neighborhood committee secretaries in 13 streets in 5 districts of Shanghai through field visits, interviews and exchanges. Every secretary of the neighborhood committee interviewed has a different personality and a unique conversation style. It is very important to dispel their worries, build trust quickly and speak freely. In the process of communicating with the secretaries of the neighborhood committees, we groped for an interview method of "sincerely eliminating barriers, bringing people closer with enthusiasm and opening the topic with empathy", and gained a lot of valuable first-hand information and work experience from the interviews with them. I am deeply impressed that in order to deeply understand community governance, I chose the community where Shanghai’s first "Habitat Garden" was born as a research sample and went to investigate it many times. The secretary of the neighborhood committee explained to me in detail the reasons, process and difficulties of building the "Habitat Garden", and the community residents vividly talked to me about how they divided their work to maintain the daily operation of the Habitat Garden, and what changes the garden brought to their daily lives. In view of what they said, I deeply learned and understood: how to promote the new practice of community governance by giving full play to the subjective initiative of residents and do a good job in people’s livelihood.
Third, adhere to the "three unifications" and find the right research countermeasures
The purpose of investigation is to solve the problem. Comrade Mao Zedong once pointed out: "Investigation is like pregnancy in October, and solving the problem is like giving birth once. To solve a problem, we must obtain a lot of materials through investigation and study, and then analyze and synthesize the materials to get the fundamental solution to the problem. " How to put forward the investigation countermeasures pertinently should achieve three unifications.
Adhere to the unity of integrity and innovation. The process of writing an investigation report is a process of constantly sorting out, summarizing, analyzing and refining the information obtained in the investigation, and it is a process of "removing the rough and selecting the essence, removing the false and retaining the true". Valuable research countermeasures should not only hold the position and the direction; It is also necessary to explore and innovate, identify the problem accurately, dig deep into the root causes, implement the plan, do not stick to stereotypes, constantly innovate the thinking and methods of solving problems, and solve the problems found in the investigation with new ideas and new methods.
Adhere to the unity of simplicity and effectiveness. The research report is for the convenience of leaders to make decisions. If an excellent scheme and countermeasure is to be stable and reliable, it must be concise and effective. In fact, the core of the unity of simplicity and effectiveness needs to achieve three "haves": First, it is organized. The solution to the problem needs to be clear-cut and clear-cut. The second is to be targeted. Analyze the root causes and put forward targeted, innovative and operable countermeasures and suggestions; Third, it is well founded. Countermeasures should be well analyzed and meaningful, and each argument should be supported by strict logic and objective data, and each argument should be supported by true and sufficient arguments.
Adhere to the unity of universality and particularity. To sum up the countermeasures in the investigation report, we should accurately grasp the representativeness of the problems and pay attention to distinguishing the relationship between common problems and special cases. Through in-depth and systematic analysis of the collected specific information, we can find out the essential characteristics of the problem. We should not exaggerate or narrow the severity of the problem by subjective feelings in the process of investigation, and confuse common problems with special situations, which will lead to the proposed countermeasures being blind and misleading.
In short, we should try our best to dig deep into the countermeasures on the basis of fully understanding the facts, deeply analyze the information collected from the investigation, grasp the real problem from the contradiction point, find the causal chain from the breakthrough point, and find the countermeasures from the key points, and strive to form a high-quality investigation report with accurate problems and pragmatic and effective countermeasures, so as to achieve the good effect of "adjusting the value and applying the research".
(The author is Chen Yubo, doctor of law, cadre of the National Law Office of the National People’s Congress Standing Committee (NPCSC) Law Committee)
Source: China People’s Congress Network
Reporting/feedback